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ViiV receives results from NEAT study

25 July 2017 13:50

ViiV Healthcare, owned by GlaxoSmithKline, has announced positive interim results from the NEAT 02 study of more than 400 patients with HIV and high cardiovascular risk.

The study was conducted by the NEAT-ID group with support from ViiV Healthcare and St Stephen's AIDS Trust (SSAT), and showed that switching virologically suppressed patients at high risk of cardiovascular disease (CVD) from a boosted protease inhibitor regimen (PI/r) to a dolutegravir-based regimen maintained viral suppression while decreasing blood lipids. The study results were presented at the annual conference of the International AIDS Society (IAS) in Paris, France.

CVD is a leading cause of morbidity and mortality across the world1 and certain antiretroviral agents are associated with adverse changes in blood lipids, an established factor contributing to risk for CVD. The NEAT study sought to evaluate the safety and efficacy of switching to dolutegravir in patients with HIV and high cardiovascular risk.

Overall, 415 patients from six European countries were randomised to switch from a boosted PI to dolutegravir or to remain on a boosted PI for 48 weeks. Of these, 89% were men, 87% were older than 50 years and 74% had a Framingham CVD risk score of greater than 10% over the next 10 years.

The study demonstrated that switching to a dolutegravir-based regimen in virologically suppressed HIV-infected patients with high CVD risk was non-inferior compared with continuing a boosted PI-based regimen, with no emergent resistance mutations in any of the groups. Total cholesterol and other lipid fractions (except high-density lipoprotein cholesterol) improved significantly (p<0.001) in the dolutegravir group. There was no significant difference in severe, grade 3 or 4 or treatment-modifying adverse events.

Michael Aboud, Vice President and Global Medical Lead for dolutegravir, said: "Simply having HIV is a risk factor for premature CVD, so it is important for people with HIV and other CVD risk factors to have effective treatment options that avoid adding to that risk. We were pleased to collaborate with the NEAT-ID group on this study that showed switching to a dolutegravir-based regimen not only maintained viral suppression in a population with HIV and high risk for CVD, but also improved their overall lipid profile."

At 1:50pm: (LON:GSK) GlaxoSmithKline PLC share price was -10.25p at 1585.25p

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